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CI # 51297 Does maternal caffeine intake affect infant birth weight?: Home

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Cochrane Library - CDSR (Systematic Reviews)

1

caffeine and birth weight

Effects of restricted caffeine intake by mother on fetal, neonatal and pregnancy outcome   Shayesteh Jahanfar and Sharifah Halimah Jaafar. Published Online: 28 FEB 2013. Assessed as up-to-date: 29 NOV 2012

PubMed

Systematic reviews & meta analyses

7 (birth weight[tw] OR birth weight[mh] OR low birth weight infant[mh] OR fetal growth retardation[mh] OR ((growth restriction[tw] OR fetal growth[tw]) AND (infant[tw] OR infants[tw] OR fetal[tw] OR fetus[tw]))) AND (caffeine[ti] OR caffeinated[ti] OR caffeine[majr]) AND (pregnancy OR pregnant) AND (Meta Analysis[pt] OR meta analy*[tw] OR metaanaly*[tw] OR systematic review*[tw] OR data synthesis[tw] OR data extraction[tw] OR Cochrane Database Syst Rev[ta]) AND english[la]
PubMed

Cohort studies, RCTs; duplicates removed

33 (birth weight[tw] OR birth weight[mh] OR low birth weight infant[mh] OR fetal growth retardation[mh] OR ((growth restriction[tw] OR fetal growth[tw]) AND (infant[tw] OR infants[tw] OR fetal[tw] OR fetus[tw]))) AND (caffeine[ti] OR caffeinated[ti] OR caffeine[majr]) AND (pregnancy OR pregnant) AND (Cohort Studies[mh] OR cohort*[tw] OR compar*[tw] OR cross-sectional[tw] OR cross-sectional studies[mh] OR follow-up[tw] OR followup[tw] OR follow up[tw] OR longitudinal*[tw] OR multivariate[tw] OR population surveillance/methods[mh] OR population-based study[tw] OR prospective*[tw] OR random* OR randomized controlled trial[pt] OR reproducib*[tw] OR Reproducibility of Results[mh]) NOT (Meta Analysis[pt] OR meta analy*[tw] OR metaanaly*[tw] OR systematic review*[tw] OR data synthesis[tw] OR data extraction[tw] OR Cochrane Database Syst Rev[ta]) AND english[la] AND humans[mh]
PubMed

Guidelines

0 (birth weight[tw] OR birth weight[mh] OR low birth weight infant[mh] OR fetal growth retardation[mh] OR ((growth restriction[tw] OR fetal growth[tw]) AND (infant[tw] OR infants[tw] OR fetal[tw] OR fetus[tw]))) AND (caffeine[ti] OR caffeine[majr]) AND (pregnancy OR pregnant) AND (Guideline[pt] OR Practice Guideline[pt] OR Consensus Development Conference[pt] OR Consensus Development Conference, NIH[pt] OR practice guidelines as topic[mh]) AND english[la]
National Guideline Clearinghouse   See DynaMed below for link to ACOG guideline on caffeine consumption during pregnancy
FPIN CIs, PURLS, HDAs 1

caffeine and pregnancy.

Should caffeine be restricted during pregnancy? Evidence Based Practice. 2012; 15(4): 07.

DynaMed 1

From DynaMed:

Caffeine Use

  • American College of Obstetricians and Gynecologists (ACOG) Committee Opinion 462 on moderate caffeine consumption during pregnancy can be found in Obstet Gynecol 2010 Aug;116(2 Pt 1):467, reaffirmed 2013 Sep, commentary can be found in ACOG News Release 2010 Jul 21
    • ACOG committee opinion states
      • moderate caffeine consumption (< 200 mg per day) does not appear to be major contributor to risk of miscarriage or preterm birth
      • conclusions regarding high caffeine consumption and its contribution to risk of miscarriage cannot be made at this time
avoidance of high caffeine doses generally recommended based on observational evidence
  • caffeine consumption during pregnancy associated with increased risk of low birth weight
    • based on systematic review of observational studies
    • systematic review of 13 prospective observational studies evaluating effect of maternal caffeine use during pregnancy on risk of low birth weight
    • intrauterine growth restriction and small for gestational age were included in low birth weight outcomes
    • compared to no or very low caffeine intake, increased risk of low birth weight with
      • low caffeine intake (50-149 mg/day) (relative risk [RR] 1.13, 95% CI 1.06-1.21) in analysis of 5 studies
      • moderate caffeine intake (150-349 mg/day) (RR 1.38, 95% CI 1.18-1.62) in analysis of 7 studies
      • high caffeine intake (≥ 350 mg/day) (RR 1.6, 95% CI 1.24-2.08) in analysis of 8 studies, results limited by significant heterogeneity
    • Reference - BMC Med 2014 Sep 19;12(1):174

Author Information

Clinician Authors:Taralee Adams and Gary Kelsberg

Librarian Author:  Sarah Safranek

Search Due Date: February 2015

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