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CI # 51544 How safe and effective is fecal transplant in preventing C. diff recurrence?: search

Search Summary

FPIN CIs, PURLS, HDAs 1 What treatments are effective for C difficile colitis in adults? Evidence Based Practice. 2015; 18(4):1-2.

Cochrane Library - CDSR (Systematic Reviews)

1 Protocol (incomplete/review in progress). Hundal R, Kassam Z, Johnstone J, Lee C, Marshall JK. Fecal transplantation for recurrent or refractory Clostridium difficile diarrhea. Cochrane Database of Systematic Reviews 2011, Issue 9. Art. No.: CD009295. DOI: 10.1002/14651858.CD009295.
Cochrane Library - Other Systematic Reviews (DARE)  

Fecal microbiota transplantation for Clostridium difficile infection: systematic review and meta‐analysis (Structured abstract). Original article: Kassam Z, et. al. Am J Gastroenterol. 2013;108(4):500-508.

Cammarota G, Ianiro G, Gasbarrini A. Fecal microbiota transplantation for the
treatment of Clostridium difficile infection: a systematic review
. J Clin
Gastroenterol. 2014 Sep;48(8):693-702. doi: 10.1097/MCG.0000000000000046. Review.
PubMed PMID: 24440934.

Cochrane Library - Clinical Trials   same strategy used as for CDSR above
PubMed

Systematic reviews & meta analyses

15 (fecal microbiota transplantation[mh] OR fecal microbiota transplant*[tw] OR intestinal microbiota transfer*[tw] OR fecal transplant*[tw] OR fecotherapy[tw] OR faecotherapy[tw] OR faecal microbiota transplant*[tw] OR faecal transplant*[tw] OR fecal donation[tw] OR faecal donation[tw] OR fecal suspension[tw] OR faecal suspension[tw] OR fecal transfer[tw] OR faecal transfer[tw] OR fecal infusion[tw] OR faecal infusion[tw] OR donor feces[tw] OR donor faeces[tw]) AND (clostridium infections[majr] OR clostridium difficile[majr] OR clostridium difficile[tw] OR clostridium infection*[tw] OR c difficile[tw] OR clostridium[tw]) AND (recurrence[mh] OR recurrent[tw] OR recurrence*[tw] OR reinfection*[tw] OR re infection*[tw] OR re-infection*[tw] relapse*[tw] OR relapsing[tw] OR refractory[tw] OR second line[tw] OR secondline[tw] OR rescue[tw] OR salvage[tw] OR salvage therapy[mh] OR retreatment[mh] OR re-treat*[tw] OR retreat*[tw]) AND (Meta Analysis[pt] OR meta analy*[tw] OR metaanaly*[tw] OR systematic review*[tw] OR data synthesis[tw] OR data extraction[tw] OR Cochrane Database Syst Rev[ta] OR systematic[sb]) AND english[la]
PubMed

RCTs; duplicates removed

6 (fecal microbiota transplantation[mh] OR fecal microbiota transplant*[tw] OR intestinal microbiota transfer*[tw] OR fecal transplant*[tw] OR fecotherapy[tw] OR faecotherapy[tw] OR faecal microbiota transplant*[tw] OR faecal transplant*[tw] OR fecal donation[tw] OR faecal donation[tw] OR fecal suspension[tw] OR faecal suspension[tw] OR fecal transfer[tw] OR faecal transfer[tw] OR fecal infusion[tw] OR faecal infusion[tw] OR donor feces[tw] OR donor faeces[tw]) AND (clostridium infections[majr] OR clostridium difficile[majr] OR clostridium difficile[tw] OR clostridium infection*[tw] OR c difficile[tw] OR clostridium[tw]) AND (recurrence[mh] OR recurrent[tw] OR recurrence*[tw] OR reinfection*[tw] OR re infection*[tw] OR re-infection*[tw] relapse*[tw] OR relapsing[tw] OR refractory[tw] OR second line[tw] OR secondline[tw] OR rescue[tw] OR salvage[tw] OR salvage therapy[mh] OR retreatment[mh] OR re-treat*[tw] OR retreat*[tw]) AND (randomized controlled trial[pt] OR ((random*[tw] AND trial*[tw]) NOT medline[sb])) AND english[la]
PubMed

other trials; treatment outcomes; duplicates removed

53 (fecal microbiota transplantation[mh] OR fecal microbiota transplant*[tw] OR intestinal microbiota transfer*[tw] OR fecal transplant*[tw] OR fecotherapy[tw] OR faecotherapy[tw] OR faecal microbiota transplant*[tw] OR faecal transplant*[tw] OR fecal donation[tw] OR faecal donation[tw] OR fecal suspension[tw] OR faecal suspension[tw] OR fecal transfer[tw] OR faecal transfer[tw] OR fecal infusion[tw] OR faecal infusion[tw] OR donor feces[tw] OR donor faeces[tw]) AND (clostridium infections[majr] OR clostridium difficile[majr] OR clostridium difficile[tw] OR clostridium infection*[tw] OR c difficile[tw] OR clostridium[tw]) AND (recurrence[mh] OR recurrent[tw] OR recurrence*[tw] OR reinfection*[tw] OR re infection*[tw] OR re-infection*[tw] relapse*[tw] OR relapsing[tw] OR refractory[tw] OR second line[tw] OR secondline[tw] OR rescue[tw] OR salvage[tw] OR salvage therapy[mh] OR retreatment[mh] OR re-treat*[tw] OR retreat*[tw]) AND (clinical study[pt] OR "outcome assessment (health care)"[mh] OR treatment outcome* OR prognosis[mh] OR clinical effectiveness[tw] OR patient relevant outcome*[tw] OR clinical efficacy[tw] OR treatment effectiveness[tw] OR costs and cost analysis[mh] OR clinical trial[tw] OR cohort[tw] OR prospective[tw] OR observational[tw] OR epidemiologic studies[mh]) AND english[la]
PubMed

Guidelines

3 (fecal microbiota transplantation[mh] OR fecal microbiota transplant*[tw] OR intestinal microbiota transfer*[tw] OR fecal transplant*[tw] OR fecotherapy[tw] OR faecotherapy[tw] OR faecal microbiota transplant*[tw] OR faecal transplant*[tw] OR fecal donation[tw] OR faecal donation[tw] OR fecal suspension[tw] OR faecal suspension[tw] OR fecal transfer[tw] OR faecal transfer[tw] OR fecal infusion[tw] OR faecal infusion[tw] OR donor feces[tw] OR donor faeces[tw]) AND (clostridium infections[majr] OR clostridium difficile[majr] OR clostridium difficile[tw] OR clostridium infection*[tw] OR c difficile[tw] OR clostridium[tw]) AND (guideline*[ti] OR recommendation*[ti] OR treatment guidance[ti] OR Guideline[pt] OR Practice Guideline[pt] OR Consensus Development Conference[pt] OR Consensus Development Conference, NIH[pt]) AND english[la]
National Guideline Clearinghouse 1

 

Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections. Am J Gastroenterol. 2013 Apr;108(4):478-98.

 

Author Information

Clinician Authors: Jessica Shih, Shawn Meyers and Jon Neher

Librarian:  Sarah Safranek

Search Due Date: Oct 2016

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