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CI # 51524 How effective is metformin in the treatment of non-alcoholic fatty liver disease?: search

Search Summary

FPIN CIs, PURLS, HDAs  

Metformin use in adolescents. Am Fam Physician. 2013. 87(8).

Therapies for nonalcoholic steatohepatitis (NASH). Evidence Based Practice. 2011. 14(5): 01-02.

Statins for patients with nonalcoholic fatty liver? J Fam Pract. 2011. 60(9): 536-

Are thiazolidinediones effective in the treatment of nonalcoholic steatohepatitis (NASH)? (also discusses metformin) Evidence Based Practice. 2014. 17(5): E06-E07.

DynaMed   NAFLD > see treatment > medications > Metformin

Cochrane Library - CDSR (Systematic Reviews)

0  
Cochrane Library - Other Systematic Reviews (DARE) 2

Insulin sensitizers in treatment of nonalcoholic fatty liver disease: systematic review (Structured abstract). Original article: Chavez-Tapia NC, et. al. World J Gastroenterol. 2006; 12(48): 7826-31.

Pharmacologic interventions for nonalcoholic fatty liver disease in adults and children: a systematic review (Structured abstract). Original article: Socha P., et al. J Pediatric Gastroenterol Nutr. 2009; 48(5):587-596.

 

PubMed

Systematic reviews & meta analyses

7 ((fatty liver[mh] OR fatty liver[ti] OR steatohepatitis[ti]) AND (nonalcoholic[tw] OR non-alcoholic[tw] OR non alcoholic[tw])) AND (metformin[ti] OR metformin/tu[mh] OR metformin[majr]) AND (Meta Analysis[pt] OR meta analy*[tw] OR metaanaly*[tw] OR systematic review*[tw] OR data synthesis[tw] OR data extraction[tw] OR Cochrane Database Syst Rev[ta])
PubMed

RCTs; duplicates removed

33 ((fatty liver[mh] OR fatty liver[ti] OR steatohepatitis[ti]) AND (nonalcoholic[tw] OR non-alcoholic[tw] OR non alcoholic[tw])) AND (metformin[ti] OR metformin/tu[mh] OR metformin[majr]) AND (randomized controlled trial[pt] OR (random*[tiab] AND trial*[tiab])) NOT (Meta Analysis[pt] OR meta analy*[tw] OR metaanaly*[tw] OR systematic review*[tw] OR data synthesis[tw] OR data extraction[tw] OR Cochrane Database Syst Rev[ta]) AND english[la]
PubMed

Guidelines; duplicates removed

1 ((fatty liver[mh] OR fatty liver[ti] OR steatohepatitis[ti]) AND (nonalcoholic[tw] OR non-alcoholic[tw] OR non alcoholic[tw])) AND (metformin[ti] OR metformin/tu[mh] OR metformin[majr]) AND (Guideline[pt] OR Practice Guideline[pt] OR Consensus Development Conference[pt] OR Consensus Development Conference, NIH[pt]) AND english[la]
National Guideline Clearinghouse   The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

Bibliographic source: Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, Charlton M,
Sanyal AJ. Hepatology. 2012 Jun;55(6):2005-23. doi: 10.1002/hep.25762. PubMed PMID: 22488764.

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Clinician Authors: Samira Farah, Thu Nguyen and Gary Kelsberg

Librarian:  Sarah Safranek

Search Due Date: Feb 2016

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