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CI # 51572 How safe and effective is ondansetron for nausea and vomiting in pregnancy?: search

Search Summary

Cochrane Library - CDSR (Systematic Reviews)

1 Boelig RC, Barton SJ, Saccone G, Kelly AJ, Edwards SJ, Berghella V. Interventions for treating hyperemesis gravidarum. Cochrane Database Syst Rev. 2016 May 11;(5):CD010607.
PubMed

Systematic reviews & meta analyses

5 (zofran OR ondansetron) AND (pregnancy[tw] OR pregnant[tw]) AND (nausea/therapy[mh] OR vomiting/therapy[mh] OR ((hyperemesis[ti] OR nausea[ti] OR vomiting[ti] OR morning sickness[ti]) AND (treatment OR therapy OR therapies OR management))) AND (Meta Analysis[pt] OR meta analy*[ti] OR metaanaly*[ti] OR systematic review*[ti] OR data synthesis[tw] OR data extraction[tw] OR Cochrane Database Syst Rev[ta]) AND english[la]
PubMed

RCTs; duplicates removed

14 (zofran OR ondansetron) AND ((pregnancy[tw] OR pregnant[tw]) NOT (caesarean[tw] OR cesarean[tw])) AND (nausea/therapy[mh] OR vomiting/therapy[mh] OR ((hyperemesis[ti] OR nausea[ti] OR vomiting[ti] OR morning sickness[ti]) AND (treatment OR therapy OR therapies OR management))) AND (randomized controlled trial[pt] OR ((random*[tw] AND trial*[tw]) NOT medline[sb])) NOT (Meta Analysis[pt] OR meta analy*[ti] OR metaanaly*[ti] OR systematic review*[ti] OR data synthesis[tw] OR data extraction[tw] OR Cochrane Database Syst Rev[ta])
Cochrane Library - Clinical Trials 2

Comparing neonatal outcome following the use of ondansetron versus vitamin B6 in pregnant females with morning sickness: a randomized clinical trial. Shahraki Z , Bonjar ZSH , Forghani F and Nakhai R. Journal of comprehensive pediatrics, 2016, 7(4) (no pagination) Online Publication Date: 2017.

A comparison of Ondansetron and promethasin in treating hyperemesis gravidarum. Eftekhari N and Mehralhasani Y. Journal of Kerman University Medical Sciences, 2013, 20(4): 534.

additional RCTs from Embase database 2

The effect of Ondansetron and Metoclopramide in nausea and vomiting of pregnancy. Ghahiri AA, Abdi F, Mastoo R, Ghasemi M. Journal of Isfahan Medical School. 2011 29:131.

Progressive muscle relaxation in hyperemesis gravidarum. Gawande S, Vaidya M, Tadke R, Kirpekar V, Bhave S. Journal of SAFOG. 2011 3(1): 28-32.

PubMed

Clinical Trials; duplicates removed

26 (zofran OR ondansetron) AND ((pregnancy[tw] OR pregnant[tw]) NOT (caesarean[tw] OR cesarean[tw])) AND (nausea/therapy[mh] OR vomiting/therapy[mh] OR ((hyperemesis[ti] OR nausea[ti] OR vomiting[ti] OR morning sickness[ti]) AND (treatment OR therapy OR therapies OR management))) AND (Clinical Trial[pt] OR Multicenter Study[pt] OR trial[tw] OR trials[tw] OR multicenter[tw] OR multicentre[tw] OR multi center[tw] OR multi centre[tw] OR placebo*[tw] OR double blind*[tw] OR Treatment Outcome[mh] OR outcome*[tw] OR evidence based[tw]) NOT (randomized controlled trial[pt] OR ((random*[tw] AND trial*[tw]) NOT medline[sb]) OR Meta Analysis[pt] OR meta analy*[ti] OR metaanaly*[ti] OR systematic review*[ti] OR data synthesis[tw] OR data extraction[tw] OR Cochrane Database Syst Rev[ta] OR Guideline[pt] OR Practice Guideline[pt] OR Consensus Development Conference[pt] OR Consensus Development Conference, NIH[pt] OR practice guidelines as topic[mh] OR consensus[ti] OR guideline*[ti] OR guidance[ti])
PubMed

Adverse effects

47 (ondansetron/adverse effects[mh] OR (((ondansetron OR zofran) AND (safe OR safety OR adverse OR birth defect*[tw] OR malformation* OR teratogen*)) NOT medline[sb])) AND pregnancy
PubMed

Guidelines; duplicates removed

0 (zofran OR ondansetron) AND (pregnancy[tw] OR pregnant[tw]) AND (Guideline[pt] OR Practice Guideline[pt] OR Consensus Development Conference[pt] OR Consensus Development Conference, NIH[pt] OR practice guidelines as topic[mh] OR consensus[ti] OR guideline*[ti] OR guidance[ti])
National Guideline Clearinghouse 0 ondansetron and pregnancy
FPIN CIs, PURLS, HDAs   What is the best treatment for hyperemesis gravidarum? Evidence-based practice 13, no. 01 (2010): 14

Author Information

Clinician Authors: Kimberly Collins, Chris Vincent, and Megan Wilson

Librarian:  Sarah Safranek

Search Due Date: Oct 2017

Manuscript Due Date:

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Librarian Contact Information:

Sarah Safranek, MLIS
Information Management Librarian
safranek@uw.edu
guides.lib.uw.edu/hsl/safranek

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