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CI # 51622 How effective and safe is megestrol for cachexia in patients with cancer?: search

Search Summary

Cochrane Library - CDSR (Systematic Reviews)

   Ruiz Garcia V, López-Briz E, Carbonell Sanchis R, Gonzalvez Perales JL, Bort-Marti S. Megestrol acetate for treatment of anorexia-cachexia syndrome. Cochrane Database Syst Rev. 2013 Mar 28;(3):CD004310.
PubMed

Systematic reviews & meta analyses

 12 (cachexia/therapy[mh] OR anorexia/therapy[mh] OR anorexia[ti] OR cachexia[ti] OR cachetic[ti] OR anorexic[ti] OR weight loss[majr] OR weight loss[ti] OR appetite/drug effects[mh] OR appetite stimulants/therapeutic use[mh])
AND
(neoplasms/complications[mh] OR neoplasms[majr] OR cancer*[ti] OR neoplas*[ti] OR ((cancer*[tiab] OR neoplas*[tiab]) NOT medline[sb]))
AND
(megestrol acetate/therapeutic use[mh] OR megestrol[tiab])
NOT
(animals[mh] NOT humans[mh])
AND 
(Meta Analysis[pt] OR meta analy*[ti] OR metaanaly*[ti] OR systematic review*[tiab] OR data synthesis[tw] OR data extraction[tw] OR Cochrane Database Syst Rev[ta] OR review literature as topic[mh]) AND english[la]
PubMed

RCTs; duplicates removed

 47 (cachexia/therapy[mh] OR anorexia/therapy[mh] OR anorexia[ti] OR cachexia[ti] OR cachetic[ti] OR anorexic[ti] OR weight loss[majr] OR weight loss[ti] OR appetite/drug effects[mh] OR appetite stimulants/therapeutic use[mh]) AND (neoplasms/complications[mh] OR neoplasms[majr] OR cancer*[ti] OR neoplas*[ti] OR ((cancer*[tiab] OR neoplas*[tiab]) NOT medline[sb])) AND (megestrol acetate/therapeutic use[mh] OR megestrol[tiab]) NOT (animals[mh] NOT humans[mh]) AND (randomized controlled trial[pt] OR (random*[tiab] NOT medline[sb])) NOT (Meta Analysis[pt] OR meta analy*[ti] OR metaanaly*[ti] OR systematic review*[tiab] OR data synthesis[tw] OR data extraction[tw] OR Cochrane Database Syst Rev[ta] OR review literature as topic[mh]) AND english[la]
PubMed

other Clinical Trials & epidemiologic studies ; duplicates removed

 45 (cachexia/therapy[mh] OR anorexia/therapy[mh] OR anorexia[ti] OR cachexia[ti] OR cachetic[ti] OR anorexic[ti] OR weight loss[majr] OR weight loss[ti] OR appetite/drug effects[mh] OR appetite stimulants/therapeutic use[mh]) AND (neoplasms/complications[mh] OR neoplasms[majr] OR cancer*[ti] OR neoplas*[ti] OR ((cancer*[tiab] OR neoplas*[tiab]) NOT medline[sb])) AND (megestrol acetate/therapeutic use[mh] OR megestrol[tiab]) NOT (animals[mh] NOT humans[mh]) AND (Clinical Trial[pt] OR Multicenter Study[pt] OR multicenter[tw] OR multicentre[tw] OR multi center[tw] OR multi centre[tw] OR placebo*[tw] OR double blind*[tw] OR Treatment Outcome[mh] OR outcome*[tw] OR trial[tiab] OR trials[tiab] OR comparative study[pt] OR epidemiologic studies[mh]) NOT (randomized controlled trial[pt] OR (random*[tiab] NOT medline[sb]) OR Meta Analysis[pt] OR meta analy*[ti] OR metaanaly*[ti] OR systematic review*[tiab] OR data synthesis[tw] OR data extraction[tw] OR Cochrane Database Syst Rev[ta] OR review literature as topic[mh]) AND english[la]
PubMed

Guidelines; duplicates removed

 12

(appetite[mh] OR appetite stimulants[mh] OR appetite[tiab] OR anorexia/therapy[mh] OR cachexia/therapy[mh] OR weight loss/pc[mh]) AND (neoplasms[mh] OR oncology[tiab] OR cancer*[tiab] OR neoplas*[tiab]) AND (Guideline[pt] OR Practice Guideline[pt] OR ((guideline*[ti] OR guidance[ti] OR recommendation*[ti]) NOT medline[sb] AND 2015:3000[pdat])) 
FPIN CIs, PURLS  

Is megestrol acetate safe and effective for malnourished nursing home residents? J Fam Pract. 67 (2) 2018 112-113.

Should we use appetite stimulants for malnourished elderly patients? J Family Pract. 56(9) 2007: 761-762.

What medications are effective in the treatment of anorexia/cachexia associated with advanced cancer? Evidence-Based Practice. March 2013; 16(3):9-10.

 

Author Information

Clinician Authors: Mariatou Sisay, Meagan Wong and Jon Neher

Librarian:  Sarah Safranek

Search Due Date: Nov 2018

Manuscript Due Date:

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Librarian Contact Information:

Sarah Safranek, MLIS
safranek@uw.edu